pentobarbital will reduce the level or effect of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can reduce panobinostat concentrations by ~70